The options under Large Image Presentation impact the viewing of full-size images in your gallery, the slideshow.
Use the Presentation :desktop option to access configuration options for each of them presentation types.
The gallery will use up to three different views:
It's best-practice to configure each of these views for your gallery, in the above listed order.
For example, let's say I want to use Highslide for desktop, Touch for mobile. Then I should configure my presentations in this sequence:
The Turning Gate
Creating webbly, wobbly, Lightroomy things since 2007.